diclofenac

diclofenac

Structure of diclofenac with ball and stick model
Clinical data
Pronunciation	/daɪˈkloʊfənæk/ or /dɪklɒˈfɛnæk/
Trade names	Voltaren, others
AHFS/Drugs.com	Monograph
MedlinePlus	a689002
License data	US DailyMed: Diclofenac
Pregnancy category	AU: C
Routes of administration	Orally, rectal, intramuscular, intravenous, topical, ophthalmic
Drug class	Nonsteroidal anti-inflammatory agents
ATC code	D11AX18 (WHO) M01AB05 (WHO), M02AA15 (WHO), S01BC03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) / S3 / S2 CA: ℞-only UK: POM (Prescription only) / P / GSL US: ℞-only / OTC In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	More than 99%
Metabolism	Liver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation; no active metabolites exist
Onset of action	Within 4 hours (gel), 30 min (non-gel)
Elimination half-life	1.2–2 h (35% of the drug enters enterohepatic recirculation)
Excretion	35% bile, 65% urine
Identifiers
IUPAC name [2-(2,6-Dichloroanilino)phenyl]acetic acid
CAS Number	15307-86-5
PubChem CID	3033
IUPHAR/BPS	2714
DrugBank	DB00586
ChemSpider	2925
UNII	144O8QL0L1
KEGG	D07816
ChEBI	CHEBI:47381
ChEMBL	ChEMBL139
PDB ligand	DIF (PDBe, RCSB PDB)
Chemical and physical data
Formula	C14H11Cl2NO2
Molar mass	296.147 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) Key:DCOPUUMXTXDBNB-UHFFFAOYSA-N
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Főnév

diclofenac (tsz. diclofenacs)

1. (gyógyszertan) diklofenák

További információk

• diclofenac - Szótár.net (en-hu)
• diclofenac - Sztaki (en-hu)
• diclofenac - Merriam–Webster
• diclofenac - Cambridge
• diclofenac - WordNet
• diclofenac - Яндекс (en-ru)
• diclofenac - Google (en-hu)
• diclofenac - Wikidata
• diclofenac - Wikipédia (angol)