hydrocortisone

hydrocortisone

Clinical data
Trade names	Cortef, others
Other names	Cortisol; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 11β,17α,21-Trihydroxyprogesterone
AHFS/Drugs.com	Monograph
MedlinePlus	a682206
License data	US DailyMed: Hydrocortisone
Pregnancy category	AU: A
Routes of administration	By mouth, intravenous, topical, rectal
Drug class	Glucocorticoid; Mineralocorticoid
ATC code	A01AC03 (WHO) A07EA02 (WHO), C05AA01 (WHO), D07AA02 (WHO), D07XA01 (WHO), H02AB09 (WHO), S01BA02 (WHO), S01CB03 (WHO), S02BA01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) / S3 / S2 UK: POM (Prescription only) / P / GSL US: OTC / Rx-only EU: OTC / Rx-only
Pharmacokinetic data
Bioavailability	Oral: 96 ± 20%
Protein binding	92 ± 2% (92–93%)
Metabolism	11β-HSDsTooltip 11β-Hydroxysteroid dehydrogenases, others
Metabolites	Cortisone, others
Onset of action	Oral: 1.2 ± 0.4 hours (Tmax)
Elimination half-life	1.2–2.0 hours
Duration of action	8–12 hours
Identifiers
IUPAC name (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number	50-23-7 Y
PubChem CID	5754
DrugBank	DB00741 Y
ChemSpider	5551 Y
UNII	WI4X0X7BPJ
KEGG	D00088 Y D00165 Y
ChEBI	CHEBI:17650 Y
ChEMBL	ChEMBL389621 Y
Chemical and physical data
Formula	C21H30O5
Molar mass	362.466 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C4\C=C2/[C@]([C@H]1[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@H]3[C@@H]1CC2)C)(C)CC4
InChI InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 Y Key:JYGXADMDTFJGBT-VWUMJDOOSA-N Y
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Angol

Főnév

hydrocortisone (tsz. hydrocortisones)

1. (gyógyszertan) hidrokortizon

További információk

• hydrocortisone - Szótár.net (en-hu)
• hydrocortisone - Sztaki (en-hu)
• hydrocortisone - Merriam–Webster
• hydrocortisone - Cambridge
• hydrocortisone - WordNet
• hydrocortisone - Яндекс (en-ru)
• hydrocortisone - Google (en-hu)
• hydrocortisone - Wikidata
• hydrocortisone - Wikipédia (angol)