abiraterone

abiraterone

Clinical data
Pronunciation	a" bir a' ter one
Trade names	Zytiga, Yonsa, others
Other names	CB-7630; JNJ-212082; 17-(3-Pyridinyl)androsta-5,16-dien-3β-ol acetate, abiraterone (BAN UK), abiraterone acetate (JAN JP), abiraterone acetate (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a611046
License data	US DailyMed: Abiraterone_acetate
Pregnancy category	AU: D
Routes of administration	By mouth
Drug class	Antineoplastic
ATC code	L02BX03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only EU: Rx-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Unknown, but may be 50% at most on empty stomach
Protein binding	Abiraterone: ~99.8% (to albumin and α1-AGp)
Metabolism	Esterases, CYP3A4, SULT2A1
Metabolites	Abiraterone, others
Elimination half-life	Abiraterone: 12–24 hours
Excretion	Feces: 88% Urine: 5%
Identifiers
IUPAC name [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
CAS Number	154229-18-2 154229-19-3 (abiraterone)
PubChem CID	9821849
IUPHAR/BPS	9288
DrugBank	DBSALT001173
ChemSpider	7997598
UNII	EM5OCB9YJ6
KEGG	D09701
ChEBI	CHEBI:68639
ChEMBL	ChEMBL271227
Chemical and physical data
Formula	C26H33NO2
Molar mass	391.555 g·mol−1
3D model (JSmol)	Interactive image
Melting point	144 to 145 °C (291 to 293 °F)
SMILES CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC=C4C5=CN=CC=C5)C)C
InChI InChI=1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1 Key:UVIQSJCZCSLXRZ-UBUQANBQSA-N
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Angol

Főnév

abiraterone (tsz. abiraterones)

1. (gyógyszertan) abirateron

További információk

• abiraterone - Szótár.net (en-hu)
• abiraterone - Sztaki (en-hu)
• abiraterone - Merriam–Webster
• abiraterone - Cambridge
• abiraterone - WordNet
• abiraterone - Яндекс (en-ru)
• abiraterone - Google (en-hu)
• abiraterone - Wikidata
• abiraterone - Wikipédia (angol)