adapalene
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| Clinical data | |
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| Trade names | Differin, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604001 |
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| Routes of administration | Topical |
| Drug class | Retinoids |
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| Physiological data | |
| Receptors | Retinoic acid receptor (RAR) |
| Metabolism | Known to accumulate in the liver and GI-tract. In human, mouse, rat, rabbit, and dog cultured hepatocytes, metabolism appears to affect the methoxybenzene moiety but remains incompletely characterized. The major products of metabolism are glucuronides. Approximately 25% of the drug is metabolized; the rest is excreted as parent drug |
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| Pharmacokinetic data | |
| Bioavailability | Very lowSablon:medcn |
| Metabolism | Known to accumulate in the liver and GI-tract. In human, mouse, rat, rabbit, and dog cultured hepatocytes, metabolism appears to affect the methoxybenzene moiety but remains incompletely characterized. The major products of metabolism are glucuronides. Approximately 25% of the drug is metabolized; the rest is excreted as parent drug |
| Metabolites | Glucuronides |
| Elimination half-life | between 7 and 51 hours |
| Excretion | Bile duct |
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| Chemical and physical data | |
| Formula | C28H28O3 |
| Molar mass | 412.529 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 300 °C (572 °F) |
| Boiling point | 606.3 °C (1,123.3 °F) |
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Főnév
adapalene (tsz. adapalenes)