asenapine

asenapine

Clinical data
Trade names	Saphris, Sycrest, Secuado
Other names	ORG-5222
AHFS/Drugs.com	Monograph
MedlinePlus	a610015
License data	EU EMA: by INN US DailyMed: Asenapine US FDA: Asenapine
Pregnancy category	AU: C
Routes of administration	Sublingual, transdermal
Drug class	Atypical antipsychotic
ATC code	N05AH05 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class C1 (Other controlled substances) UK: POM (Prescription only) US: ℞-only EU: Rx-only
Pharmacokinetic data
Bioavailability	35% (sublingual), <2% (oral),
Protein binding	95%
Metabolism	hepatic (glucurinodation by UGT1A4 and oxidative metabolism by CYP1A2)
Elimination half-life	24 hours (sublingual),
Excretion	Kidney (50%), Faecal (40%; ~5–16% as unchanged drug in faeces)
Identifiers
IUPAC name (3aRS,12bRS)-rel-5-Chloro-2,3,3a,12b-tetrahydro- 2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
CAS Number	65576-45-6 N as salt: 85650-56-2
PubChem CID	163091 as salt: 6917875
IUPHAR/BPS	22
DrugBank	DB06216 as salt: DBSALT000010
ChemSpider	2300725 Y as salt: 5293095
UNII	JKZ19V908O as salt: CU9463U2E2
KEGG	D11769 as salt: D02995
ChEBI	CHEBI:71253 N as salt: CHEBI:71245
ChEMBL	ChEMBL1201756 N as salt: ChEMBL2040684
Chemical and physical data
Formula	C17H16ClNO
Molar mass	285.771 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc4cc2c(Oc1c(cccc1)[C@@H]3CN(C[C@@H]23)C)cc4
InChI InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m0/s1 Y Key:VSWBSWWIRNCQIJ-GJZGRUSLSA-N Y as salt: InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1 Key:GMDCDXMAFMEDAG-CHHFXETESA-N
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Angol

Főnév

asenapine (tsz. asenapines)

1. (gyógyszertan) aszenapin

További információk

• asenapine - Szótár.net (en-hu)
• asenapine - Sztaki (en-hu)
• asenapine - Merriam–Webster
• asenapine - Cambridge
• asenapine - WordNet
• asenapine - Яндекс (en-ru)
• asenapine - Google (en-hu)
• asenapine - Wikidata
• asenapine - Wikipédia (angol)