azacitidine

azacitidine
Clinical data
Trade names	Vidaza, Azadine, Onureg
Other names	5-Azacytidine, Azacytidine, Ladakamycin, 4-Amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one, U-18496, CC-486
AHFS/Drugs.com	Monograph
MedlinePlus	a607068
License data	US DailyMed: Azacitidine;
Pregnancy; category	AU: X (High risk);
Routes of; administration	Subcutaneous, intravenous, by mouth
ATC code	L01BC07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Elimination half-life	4 hr.
Identifiers
	IUPAC name 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one;
CAS Number	320-67-2 ;
PubChem CID	9444;
IUPHAR/BPS	6796;
DrugBank	DB00928 ;
ChemSpider	9072 ;
UNII	M801H13NRU;
KEGG	D03021 ;
ChEBI	CHEBI:2038 ;
ChEMBL	ChEMBL1489 ;
Chemical and physical data
Formula	C8H12N4O5
Molar mass	244.207 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1/N=C(\N=C/N1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N;
	InChI InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 ; Key:NMUSYJAQQFHJEW-KVTDHHQDSA-N ;
	(verify)

Angol

azacitidine (tsz. azacitidines)

↑ Azacitidine (Vidaza) Use During Pregnancy. Drugs.com , 2020. május 5.
↑ Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017. Therapeutic Goods Administration (TGA) , 2022. június 21.
↑ Health product highlights 2021: Annexes of products approved in 2021. Health Canada , 2022. augusztus 3.
↑ Forráshivatkozás-hiba: Érvénytelen <ref> címke; nincs megadva szöveg a(z) Vidaza FDA label nevű lábjegyzeteknek
↑ Onureg- azacitidine tablet, film coated. DailyMed , 2021. május 20.
↑ Onureg EPAR. European Medicines Agency , 2021. április 20.
↑ Onureg Product information. Union Register of medicinal products
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