canagliflozin

canagliflozin

Clinical data
Pronunciation	/ˌkænəɡlɪˈfloʊzɪn/ KAN-ə-glif-LOH-zin
Trade names	Invokana, Sulisent, Prominad, others
Other names	JNJ-28431754; TA-7284; (1S)-1,5-anhydro-1-C-(3-{[5-(4-fluorophenyl)thiophen-2-yl]methyl]}-4-methylphenyl)-D-glucitol
AHFS/Drugs.com	Monograph
MedlinePlus	a613033
License data	US DailyMed: Canagliflozin
Pregnancy category	AU: C
Routes of administration	By mouth
Drug class	SGLT2 inhibitor
ATC code	A10BK02 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only EU: Rx-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	65%
Protein binding	99%
Metabolism	Liver glucuronidation
Elimination half-life	11.8 (10–13) hours
Excretion	53% faecal and 33% kidney
Identifiers
IUPAC name (2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
CAS Number	842133-18-0 Y
PubChem CID	24812758
IUPHAR/BPS	4582
DrugBank	DB08907 N
ChemSpider	26333259 N
UNII	6S49DGR869
KEGG	D09592
ChEBI	CHEBI:73274 N
ChEMBL	ChEMBL2103841 N
Chemical and physical data
Formula	C24H25FO5S
Molar mass	444.517403163 g·mol−1
3D model (JSmol)	Interactive image
Melting point	98 °C (208 °F)
SMILES Cc1ccc(cc1Cc2ccc(s2)c3ccc(cc3)F)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
InChI InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1 N Key:XTNGUQKDFGDXSJ-ZXGKGEBGSA-N N
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Angol

Főnév

canagliflozin (tsz. canagliflozins)

1. (gyógyszertan) kanagliflozin

További információk

• canagliflozin - Szótár.net (en-hu)
• canagliflozin - Sztaki (en-hu)
• canagliflozin - Merriam–Webster
• canagliflozin - Cambridge
• canagliflozin - WordNet
• canagliflozin - Яндекс (en-ru)
• canagliflozin - Google (en-hu)
• canagliflozin - Wikidata
• canagliflozin - Wikipédia (angol)