cocaine

cocaine

Clinical data
Pronunciation	kə(ʊ)ˈkeɪn
Trade names	Neurocaine, Goprelto, Numbrino, others
Other names	Benzoylmethylecogine
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Cocaine
Dependence liability	Physical: Low Psychological: High
Addiction liability	High
Routes of administration	Topical, by mouth, insufflation, intravenous, inhalation
Drug class	Local anesthetic; SNDRI; Stimulant
ATC code	N01BC01 (WHO) R02AD03 (WHO), S01HA01 (WHO), S02DA02 (WHO)
Legal status
Legal status	AU: S8 (Controlled drug) BR: Class F1 (Prohibited narcotics) CA: Schedule I DE: Anlage III (Special prescription form required) NZ: Class A UK: Class A US: Schedule II UN: Narcotic Schedules I and III
Pharmacokinetic data
Bioavailability	By mouth: 33% Insufflation: 60–80% Nasal spray: 25–43%
Metabolism	Liver, CYP3A4
Metabolites	Norcocaine, benzoylecgonine, cocaethylene (when consumed with alcohol)
Onset of action	Seconds to minutes
Duration of action	20 to 90 minutes
Excretion	Kidney
Identifiers
IUPAC name Methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
CAS Number	50-36-2
PubChem CID	446220
IUPHAR/BPS	2286
DrugBank	DB00907
ChemSpider	10194104
UNII	I5Y540LHVR
KEGG	D00110
ChEBI	CHEBI:27958
ChEMBL	ChEMBL370805
PDB ligand	COC (PDBe, RCSB PDB)
Chemical and physical data
Formula	C17H21NO4
Molar mass	303.358 g·mol−1
3D model (JSmol)	Interactive image
Melting point	98 °C (208 °F)
Boiling point	187 °C (369 °F)
Solubility in water	1.8g/L (22 °C)
SMILES CN1[C@H]2CC[C@@H]1[C@@H](C(OC)=O)[C@@H](OC(C3=CC=CC=C3)=O)C2
InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1 Key:ZPUCINDJVBIVPJ-LJISPDSOSA-N
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Angol

Főnév

cocaine (tsz. cocaines)

1. (gyógyszertan) kokain

További információk

• cocaine - Szótár.net (en-hu)
• cocaine - Sztaki (en-hu)
• cocaine - Merriam–Webster
• cocaine - Cambridge
• cocaine - WordNet
• cocaine - Яндекс (en-ru)
• cocaine - Google (en-hu)
• cocaine - Wikidata
• cocaine - Wikipédia (angol)