crizotinib

crizotinib

Clinical data
Trade names	Xalkori, others
Other names	PF-02341066 1066
AHFS/Drugs.com	Monograph
MedlinePlus	a612018
License data	US DailyMed: Crizotinib
Pregnancy category	AU: D
Routes of administration	By mouth
ATC code	L01ED01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only EU: Rx-only
Pharmacokinetic data
Bioavailability	43%
Protein binding	91%
Metabolism	Liver (CYP3A4/CYP3A5-mediated)
Elimination half-life	42 hours
Excretion	Faeces (63%), urine (22%)
Identifiers
IUPAC name 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
CAS Number	877399-52-5 N
PubChem CID	11626560
IUPHAR/BPS	4903
DrugBank	DB08700 Y
ChemSpider	9801307 Y
UNII	53AH36668S
KEGG	D09731 N
ChEBI	CHEBI:64310 N
ChEMBL	ChEMBL601719 Y
PDB ligand	VGH (PDBe, RCSB PDB)
Chemical and physical data
Formula	C21H22Cl2FN5O
Molar mass	450.339403163 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1(=C(C=CC(=C1[C@H](OC2=C(N=CC(=C2)C3=C[N](N=C3)C4CCNCC4)N)C)Cl)F)Cl
InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 Y Key:KTEIFNKAUNYNJU-GFCCVEGCSA-N Y
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Angol

Főnév

crizotinib (tsz. crizotinibs)

1. (gyógyszertan) krizotinib

További információk

• crizotinib - Szótár.net (en-hu)
• crizotinib - Sztaki (en-hu)
• crizotinib - Merriam–Webster
• crizotinib - Cambridge
• crizotinib - WordNet
• crizotinib - Яндекс (en-ru)
• crizotinib - Google (en-hu)
• crizotinib - Wikidata
• crizotinib - Wikipédia (angol)