domperidone

domperidone

Clinical data
Trade names	Motilium, others
Other names	R-33812; R33812; KW-5338; KW5338; NSC-299589; NSC299589
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: B2
Routes of administration	By mouth, rectal
Drug class	D2 receptor antagonist; Prolactin releaser
ATC code	A03FA03 (WHO) QP51DX06 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) EU: Rx-only
Pharmacokinetic data
Bioavailability	Oral: 13–17% Intramuscular: 90%
Protein binding	~92%
Metabolism	Hepatic (CYP3A4/5) and intestinal (first-pass)
Metabolites	All inactive
Onset of action	30–60 minutes
Elimination half-life	7–9 hours
Excretion	Feces: 66% Urine: 32% Breast milk: small quantities
Identifiers
IUPAC name 5-Chloro-1-(1-[3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl]piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS Number	57808-66-9 Y
PubChem CID	3151
IUPHAR/BPS	965
DrugBank	DB01184 Y
ChemSpider	3039 Y
UNII	5587267Z69
KEGG	D01745 Y
ChEBI	CHEBI:31515 Y
ChEMBL	ChEMBL219916 Y
Chemical and physical data
Formula	C22H24ClN5O2
Molar mass	425.917 g·mol−1
3D model (JSmol)	Interactive image
Melting point	242.5 °C (468.5 °F)
SMILES Clc1cc2c(cc1)N(C(=O)N2)C5CCN(CCCN4c3ccccc3NC4=O)CC5
InChI InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) Y Key:FGXWKSZFVQUSTL-UHFFFAOYSA-N Y
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Angol

Főnév

domperidone (tsz. domperidones)

1. (gyógyszertan) domperidon

További információk

• domperidone - Szótár.net (en-hu)
• domperidone - Sztaki (en-hu)
• domperidone - Merriam–Webster
• domperidone - Cambridge
• domperidone - WordNet
• domperidone - Яндекс (en-ru)
• domperidone - Google (en-hu)
• domperidone - Wikidata
• domperidone - Wikipédia (angol)