dutasteride

dutasteride

Clinical data
Pronunciation	/duˈtæstəˌraɪd/ doo-TA-stə-RYDE
Trade names	Avodart, others
Other names	GG-745; GI-198745; GI-198745X; N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide
AHFS/Drugs.com	Monograph
MedlinePlus	a603001
License data	US DailyMed: Dutasteride
Pregnancy category	Not to be used during pregnancy
Routes of administration	By mouth
Drug class	5α-Reductase inhibitor
ATC code	G04CB02 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	60%
Protein binding	99%
Metabolism	Liver (CYP3A4)
Metabolites	• 4'-Hydroxydutasteride
Elimination half-life	4–5 weeks
Excretion	Feces: 40% (metabolites)
Identifiers
IUPAC name (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
CAS Number	164656-23-9 Y
PubChem CID	6918296
IUPHAR/BPS	7457
DrugBank	DB01126 Y
ChemSpider	5293502 Y
UNII	O0J6XJN02I
KEGG	D03820 Y
ChEBI	CHEBI:521033 Y
ChEMBL	ChEMBL1200969 Y
Chemical and physical data
Formula	C27H30F6N2O2
Molar mass	528.539418978 g·mol−1
3D model (JSmol)	Interactive image
Density	1.346 g/cm3 at 294 K (calculated)
SMILES FC(F)(F)c1cc(c(cc1)C(F)(F)F)NC(=O)[C@@H]3[C@]2(CC[C@H]4[C@H]([C@@H]2CC3)CC[C@H]5NC(=O)\C=C/[C@]45C)C
InChI InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1 Y Key:JWJOTENAMICLJG-QWBYCMEYSA-N Y
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Angol

Főnév

dutasteride (tsz. dutasterides)

1. (gyógyszertan) dutaszterid

További információk

• dutasteride - Szótár.net (en-hu)
• dutasteride - Sztaki (en-hu)
• dutasteride - Merriam–Webster
• dutasteride - Cambridge
• dutasteride - WordNet
• dutasteride - Яндекс (en-ru)
• dutasteride - Google (en-hu)
• dutasteride - Wikidata
• dutasteride - Wikipédia (angol)