etoposide

etoposide

Clinical data
Pronunciation	/ˌɛtoʊˈpoʊsaɪd/
Trade names	Etopophos, Toposar, Vepesid, others
Other names	VP-16; VP-16-213
AHFS/Drugs.com	Monograph
MedlinePlus	a684055
Pregnancy category	AU: D
Routes of administration	By mouth, intravenous
ATC code	L01CB01 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	Highly variable, 25 to 75%
Protein binding	97%
Metabolism	Liver (CYP3A4 involved)
Elimination half-life	Oral: 6 h., IV: 6-12 h., IV in children: 3 h.
Excretion	Kidney and fecal
Identifiers
IUPAC name 4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside], 4' -(dihydrogen phosphate)
CAS Number	33419-42-0 Y
PubChem CID	36462
IUPHAR/BPS	6815
DrugBank	DB00773 Y
ChemSpider	33510 Y
UNII	6PLQ3CP4P3
KEGG	D00125 Y as salt: D04107 Y
ChEBI	CHEBI:4911 Y
ChEMBL	ChEMBL44657 Y
Chemical and physical data
Formula	C29H32O13
Molar mass	588.562 g·mol−1
3D model (JSmol)	Interactive image
Melting point	243.5 °C (470.3 °F)
SMILES C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@@H]3c4cc5c(cc4[C@H]([C@@H]6[C@@H]3COC6=O)c7cc(c(c(c7)OC)O)OC)OCO5)O)O
InChI InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1 Y Key:VJJPUSNTGOMMGY-MRVIYFEKSA-N Y
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Angol

Főnév

etoposide (tsz. etoposides)

1. (gyógyszertan) etopozid

További információk

• etoposide - Szótár.net (en-hu)
• etoposide - Sztaki (en-hu)
• etoposide - Merriam–Webster
• etoposide - Cambridge
• etoposide - WordNet
• etoposide - Яндекс (en-ru)
• etoposide - Google (en-hu)
• etoposide - Wikidata
• etoposide - Wikipédia (angol)