febuxostat

febuxostat
Clinical data
Trade names	Uloric, Adenuric, others
AHFS/Drugs.com	Monograph
MedlinePlus	a609020
License data	US DailyMed: Febuxostat;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth
ATC code	M04AA03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; EU: Rx-only <;
Pharmacokinetic data
Bioavailability	≥84% absorbed
Protein binding	99.2% to albumin
Metabolism	via CYP1A1, 1A2, 2C8, 2C9, UGT1A1, 1A8, 1A9
Elimination half-life	~5–8 hours
Excretion	Urine (~49%, mostly as metabolites, 3% as unchanged drug); feces (~45%, mostly as metabolites, 12% as unchanged drug)
Identifiers
	IUPAC name 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-; 1,3-thiazole-5-carboxylic acid;
CAS Number	144060-53-7 ;
PubChem CID	134018;
IUPHAR/BPS	6817;
DrugBank	DB04854 ;
ChemSpider	118173 ;
UNII	101V0R1N2E;
KEGG	D01206 ;
ChEBI	CHEBI:31596;
ChEMBL	ChEMBL1164729 ;
Chemical and physical data
Formula	C16H16N2O3S
Molar mass	316.375 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc1c(OCC(C)C)ccc(c1)c2nc(c(s2)C(=O)O)C;
	InChI InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20) ; Key:BQSJTQLCZDPROO-UHFFFAOYSA-N ;
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Angol

febuxostat (tsz. febuxostats)

↑ Forráshivatkozás-hiba: Érvénytelen <ref> címke; nincs megadva szöveg a(z) drugnames nevű lábjegyzeteknek
↑ Febuxostat (Uloric) Use During Pregnancy. Drugs.com , 2019. február 22.
↑ Prescription medicines: registration of new chemical entities in Australia, 2014. Therapeutic Goods Administration (TGA) , 2022. június 21.
↑ Forráshivatkozás-hiba: Érvénytelen <ref> címke; nincs megadva szöveg a(z) Adenuric EPAR nevű lábjegyzeteknek
↑ Forráshivatkozás-hiba: Érvénytelen <ref> címke; nincs megadva szöveg a(z) EMA nevű lábjegyzeteknek