itopride

itopride
Clinical data
Trade names	Ganaton
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	A03FA07 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	~60% (Tmax = 35±5 min)
Protein binding	96%
Metabolism	Extensive hepatic (FMO1 and FMO3), primarily N-oxidation
Elimination half-life	5.7±0.3 hours
Excretion	Renal (3.7–4.1% as unchanged itopride, 75.4–89.4% as itopride-N-oxide)
Identifiers
	IUPAC name N-[[4-(2-Dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxybenzamide;
CAS Number	122898-67-3 ; as HCl: 122892-31-3;
PubChem CID	3792;
DrugBank	DB04924 ; as HCl: DBSALT002665;
ChemSpider	3660 ;
UNII	81BMQ80QRL; as HCl: 2H9NV66W0I;
KEGG	D08094 ; as HCl: D02729;
ChEBI	CHEBI:94809;
ChEMBL	ChEMBL2107457;
Chemical and physical data
Formula	C20H26N2O4
Molar mass	358.438 g·mol−1
3D model (JSmol)	Interactive image; as HCl: Interactive image;
	SMILES CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OC; ; as HCl: Cl.COC1=CC=C(C=C1OC)C(=O)NCC1=CC=C(OCCN(C)C)C=C1;
	InChI InChI=1S/C20H26N2O4/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4/h5-10,13H,11-12,14H2,1-4H3,(H,21,23) ; Key:QQQIECGTIMUVDS-UHFFFAOYSA-N ; ; as HCl: InChI=1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H; Key:ZTOUXLLIPWWHSR-UHFFFAOYSA-N-UHFFFAOYSA-N;
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Angol

itopride (tsz. itoprides)