ivabradine

ivabradine

Clinical data
Pronunciation	/ɪˈvæbrədiːn/
Trade names	Corlanor, Procoralan, others
Other names	S-16257
AHFS/Drugs.com	Monograph
MedlinePlus	a615027
License data	US DailyMed: Ivabradine
Routes of administration	By mouth
ATC code	C01EB17 (WHO) C07FX05 (WHO), C07FX06 (WHO)
Legal status
Legal status	CA: ℞-only UK: POM (Prescription only) US: ℞-only EU: Rx-only
Pharmacokinetic data
Bioavailability	40%
Protein binding	70%
Metabolism	Liver (first-pass) >50%, CYP3A4-mediated
Elimination half-life	6 hours
Excretion	Kidney and fecal
Identifiers
IUPAC name 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
CAS Number	155974-00-8 N
PubChem CID	132999
IUPHAR/BPS	2357
DrugBank	DB09083 Y
ChemSpider	117373 Y
UNII	3H48L0LPZQ
KEGG	D07165 Y
ChEBI	CHEBI:85966 N
ChEMBL	ChEMBL471737 Y
Chemical and physical data
Formula	C27H36N2O5
Molar mass	468.594 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2N(CCc1cc(OC)c(OC)cc1C2)CCCN(C[C@@H]4c3cc(OC)c(OC)cc3C4)C
InChI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1 Y Key:ACRHBAYQBXXRTO-OAQYLSRUSA-N Y
NY (what is this?)  (verify)

Angol

Főnév

ivabradine (tsz. ivabradines)

1. (gyógyszertan) ivabradin

További információk

• ivabradine - Szótár.net (en-hu)
• ivabradine - Sztaki (en-hu)
• ivabradine - Merriam–Webster
• ivabradine - Cambridge
• ivabradine - WordNet
• ivabradine - Яндекс (en-ru)
• ivabradine - Google (en-hu)
• ivabradine - Wikidata
• ivabradine - Wikipédia (angol)