metamizole

metamizole

Clinical data
Trade names	Novalgin, Algocalmin, Analgin, others
Other names	Dipyrone (BAN UK, USAN US), Sulpyrine (JAN JP)
AHFS/Drugs.com	International Drug Names
Pregnancy category	None assigned; no evidence of teratogenicity in animal studies, but use in the third trimester may cause adverse effects in the newborn or ductus arteriosus (a heart defect) due to its weak NSAID activity.
Routes of administration	Oral, IM, IV, rectal
ATC code	N02BB02 (WHO)
Legal status
Legal status	AU: Withdrawn BR: OTC (Over the counter) CA: Veterinary only DE: § 48 AMG/§ 1 MPAV (Prescription only) NZ: Prescription only UK: Withdrawn US: Veterinary only (horses) EU: Legally available
Pharmacokinetic data
Bioavailability	100% (active metabolites)
Protein binding	48–58% (active metabolites)
Metabolism	Liver
Elimination half-life	14 minutes (parent compound; parenteral); metabolites: 2–4 hour
Duration of action	4–6 hour
Excretion	Urine (96%, IV; 85%, oral), faeces (4%, IV)
Identifiers
IUPAC name [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonic acid
CAS Number	50567-35-6 68-89-3 (sodium salt)
PubChem CID	3111 522325
DrugBank	DB04817
ChemSpider	3000
UNII	934T64RMNJ
KEGG	D08188
ChEBI	CHEBI:62088
ChEMBL	ChEMBL461522
Chemical and physical data
Formula	C13H17N3O4S
Molar mass	311.356 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1ccccc1N2N(C)C(C)=C(C2=O)N(C)CS(=O)(=O)O
InChI InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20) Key:LVWZTYCIRDMTEY-UHFFFAOYSA-N
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Főnév

metamizole (tsz. metamizoles)

1. (gyógyszertan) metamizol

További információk

• metamizole - Szótár.net (en-hu)
• metamizole - Sztaki (en-hu)
• metamizole - Merriam–Webster
• metamizole - Cambridge
• metamizole - WordNet
• metamizole - Яндекс (en-ru)
• metamizole - Google (en-hu)
• metamizole - Wikidata
• metamizole - Wikipédia (angol)