methadone

methadone

Skeletal formula of methadone's enantiomers. (S) corresponds to the D-enantiomer, and (R) corresponds to the L-enantiomer.
Clinical data
Trade names	Dolophine, Methadose, Methatab, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682134
License data	US DailyMed: Methadone
Pregnancy category	AU: C
Addiction liability	High
Routes of administration	By mouth, intravenous, insufflation, sublingual, rectal
Drug class	Opioid
ATC code	N02AC52 (WHO) N07BC02 (WHO) QN02AC90 (WHO)
Legal status
Legal status	AU: S8 (Controlled drug) BR: Class A1 (Narcotic drugs) CA: Schedule I DE: Anlage III (Special prescription form required) NZ: Class B UK: Class A US: Schedule II
Pharmacokinetic data
Bioavailability	Rectal: 76% SC: 79% Oral: 41–99% IV/IM: 100%
Protein binding	85–90%
Metabolism	Liver (CYP3A4, CYP2B6 and CYP2D6-mediated)
Onset of action	Rapid
Elimination half-life	15–55 hours
Duration of action	Single dose: 4–8 h Prolonged use: • Withdrawal prevention: 1–2 days • Pain relief: 8–12 hours
Excretion	Urine, faeces
Identifiers
IUPAC name (RS)-6-(dimethylamino)-4,4-diphenylheptan-3-one
CAS Number	76-99-3 Y
PubChem CID	4095
IUPHAR/BPS	5458
DrugBank	DB00333 Y
ChemSpider	3953 Y
UNII	UC6VBE7V1Z
KEGG	D08195 Y
ChEBI	CHEBI:6807 N
ChEMBL	ChEMBL651 Y
Chemical and physical data
Formula	C21H27NO
Molar mass	309.453 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CC(N(C)C)C)=O
InChI InChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3 Y Key:USSIQXCVUWKGNF-UHFFFAOYSA-N Y
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Angol

Főnév

methadone (tsz. methadones)

1. (gyógyszertan) metadon

További információk

• methadone - Szótár.net (en-hu)
• methadone - Sztaki (en-hu)
• methadone - Merriam–Webster
• methadone - Cambridge
• methadone - WordNet
• methadone - Яндекс (en-ru)
• methadone - Google (en-hu)
• methadone - Wikidata
• methadone - Wikipédia (angol)