methotrexate

methotrexate

Clinical data
Pronunciation	/ˌmɛθəˈtrɛkˌseɪt, ˌmiː-, -θoʊ-/ ⓘ
Trade names	Trexall, Rheumatrex, Otrexup, others
Other names	MTX, amethopterin
AHFS/Drugs.com	Monograph
MedlinePlus	a682019
License data	US DailyMed: Methotrexate
Pregnancy category	AU: D
Routes of administration	By mouth, intravenous, intramuscular, subcutaneous, intrathecal
ATC code	L01BA01 (WHO) L04AX03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only EU: Rx-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	60% at lower doses, less at higher doses.
Protein binding	35–50% (parent drug), 91–93% (7-hydroxymethotrexate)
Metabolism	Hepatic and intracellular
Elimination half-life	3–10 hours (lower doses), 8–15 hours (higher doses)
Excretion	Urine (80–100%), feces (small amounts)
Identifiers
IUPAC name (2S)-2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)amino]pentanedioic acid
CAS Number	59-05-2 Y
PubChem CID	126941
IUPHAR/BPS	4815
DrugBank	DB00563 Y
ChemSpider	112728 Y
UNII	YL5FZ2Y5U1
KEGG	D00142 Y
ChEBI	CHEBI:44185 Y
ChEMBL	ChEMBL34259 Y
PDB ligand	MTX (PDBe, RCSB PDB)
Chemical and physical data
Formula	C20H22N8O5
Molar mass	454.447 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C([C@H](CCC(O)=O)NC(C1=CC=C(N(CC2=CN=C(N=C(N)N=C3N)C3=N2)C)C=C1)=O)O
InChI InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 Y Key:FBOZXECLQNJBKD-ZDUSSCGKSA-N Y
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Angol

Főnév

methotrexate (tsz. methotrexates)

1. (gyógyszertan) metotrexát

További információk

• methotrexate - Szótár.net (en-hu)
• methotrexate - Sztaki (en-hu)
• methotrexate - Merriam–Webster
• methotrexate - Cambridge
• methotrexate - WordNet
• methotrexate - Яндекс (en-ru)
• methotrexate - Google (en-hu)
• methotrexate - Wikidata
• methotrexate - Wikipédia (angol)