dimethyltryptamine

Dimethyltryptamine
Clinical data
Other names	Dimethyltryptamine; DMT; N,N-DMT
Routes of; administration	By mouth (usually with an MAOITooltip monoamine oxidase inhibitor), inhalation, insufflation, rectal, intramuscular, intravenous
Drug class	Serotonergic psychedelic (hallucinogen)
ATC code	None;
Physiological data
Source tissues	Central nervous system (exact source tissues are not fully established)
Target tissues	Central nervous system
Receptors	At least 13 receptors (e.g., serotonin, sigma, trace amine-associated)
Precursor	Tryptophan
Metabolism	Oxidative deamination (MAO-ATooltip Monoamine oxidase A), N-oxidation, N-demethylation, peroxidation
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class F2 (Prohibited psychotropics); CA: Schedule III; DE: Anlage I (Authorized scientific use only); UK: Class A; US: Schedule I; UN: Psychotropic Schedule I;
Pharmacokinetic data
Bioavailability	Very low and inactive (except with an MAOITooltip monoamine oxidase inhibitor)
Metabolism	Oxidative deamination (MAO-ATooltip Monoamine oxidase A), N-oxidation, N-demethylation, peroxidation
Metabolites	Indole-3-acetic acid (NMT) (63–97%); DMT-N-oxide (DMT-NO) (3–28%); N-Methyltryptamine; Tryptamine; Others;
Onset of action	Inhalation: 10–15 seconds; Intravenous: ≤2–5 min; Intramuscular: 2–5 min; Oral with MAOITooltip monoamine oxidase inhibitor: ≤1 hour;
Elimination half-life	Alone: 5–15 min; With an MAOITooltip monoamine oxidase inhibitor: 1–4 hours;
Duration of action	Inhalation: ≤30 min; Intravenous: ≤30 min; Intramuscular: 30–60 min; Oral with MAOITooltip monoamine oxidase inhibitor: 4–6 hours;
Excretion	Urine
Identifiers
	IUPAC name 2-(1H-Indol-3-yl)-N,N-dimethylethanamine;
CAS Number	61-50-7 ;
PubChem CID	6089;
IUPHAR/BPS	141;
DrugBank	DB01488 ;
ChemSpider	5864 ;
UNII	WUB601BHAA;
KEGG	C08302 ;
ChEBI	CHEBI:28969 ;
ChEMBL	ChEMBL12420 ;
PDB ligand	A1AFV (PDBe, RCSB PDB);
Chemical and physical data
Formula	C12H16N2
Molar mass	188.274 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.099 g/cm3
Melting point	40 °C (104 °F)
Boiling point	160 °C (320 °F) at 0.6 Torr (80 Pa) also reported as 80–135 °C (176–275 °F) at 0.03 Torr (4.0 Pa)
	SMILES CN(CCC1=CNC2=C1C=CC=C2)C;
	InChI InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3 ; Key:DMULVCHRPCFFGV-UHFFFAOYSA-N ;
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Angol

Főnév

dimethyltryptamine (tsz. dimethyltryptamines)

(gyógyszertan) dimetiltriptamin

További információk

dimethyltryptamine - Szótár.net (en-hu)
dimethyltryptamine - Sztaki (en-hu)
dimethyltryptamine - Merriam–Webster
dimethyltryptamine - Cambridge
dimethyltryptamine - WordNet
dimethyltryptamine - Яндекс (en-ru)
dimethyltryptamine - Google (en-hu)
dimethyltryptamine - Wikidata
dimethyltryptamine - Wikipédia (angol)