nefazodone

nefazodone

Clinical data
Trade names	Serzone, Dutonin, Nefadar, others
Other names	BMY-13754-1; MJ-13754-1; MJ-13754; MS-13754
AHFS/Drugs.com	Monograph
MedlinePlus	a695005
Pregnancy category	C
Routes of administration	By mouth
ATC code	N06AX06 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class C1 (Other controlled substances) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	20% (variable)
Protein binding	99% (loosely)
Metabolism	Liver (CYP3A4, CYP2D6)
Metabolites	• Hydroxynefazodone
Elimination half-life	• Nefazodone: 2–4 hours
Excretion	Urine: 55% Feces: 20–30%
Identifiers
IUPAC name 1-(3-[4-(3-chlorophenyl)piperazin-1-yl]propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one
CAS Number	83366-66-9 Y 82752-99-6 (hydrochloride)
PubChem CID	4449
IUPHAR/BPS	7247
DrugBank	DB01149 Y
ChemSpider	4294 Y
UNII	59H4FCV1TF
KEGG	D08257 Y
ChEBI	CHEBI:7494 Y
ChEMBL	ChEMBL623 Y
Chemical and physical data
Formula	C25H32ClN5O2
Molar mass	470.014 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc4cccc(N3CCN(CCCN1/N=C(\N(C1=O)CCOc2ccccc2)CC)CC3)c4
InChI InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3 Y Key:VRBKIVRKKCLPHA-UHFFFAOYSA-N Y
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Angol

Főnév

nefazodone (tsz. nefazodones)

1. (gyógyszertan) nefazodon

További információk

• nefazodone - Szótár.net (en-hu)
• nefazodone - Sztaki (en-hu)
• nefazodone - Merriam–Webster
• nefazodone - Cambridge
• nefazodone - WordNet
• nefazodone - Яндекс (en-ru)
• nefazodone - Google (en-hu)
• nefazodone - Wikidata
• nefazodone - Wikipédia (angol)