propoxyphene

propoxyphene

Clinical data
Trade names	Darvon, Darvocet
AHFS/Drugs.com	Monograph
MedlinePlus	a682325
License data	US FDA: Propoxyphene
Pregnancy category	AU: C
Addiction liability	Low
Routes of administration	By mouth, IV, rectal
ATC code	N02AC04 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class A2 (Narcotic drugs) CA: Schedule I DE: Anlage II (Authorized trade only, not prescriptible) UK: Class C US: Schedule II and Schedule IV (when in dosage form)
Pharmacokinetic data
Bioavailability	40%
Protein binding	78%
Metabolism	Liver-mediated, CYP3A4-mediated N-demethylation (major), aromatic hydroxylation (minor) and ester hydrolysis (minor)
Elimination half-life	6–12 hours; 30–36 hours (active metabolite, nordextropropoxyphene)
Excretion	Urine (major), breastmilk (minor)
Identifiers
IUPAC name (1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate
CAS Number	469-62-5 Y
PubChem CID	10100
IUPHAR/BPS	7593
DrugBank	DB00647 N
ChemSpider	9696 Y
UNII	S2F83W92TK
KEGG	D07809 Y
ChEBI	CHEBI:51173 Y
ChEMBL	ChEMBL1213351 Y
Chemical and physical data
Formula	C22H29NO2
Molar mass	339.479 g·mol−1
3D model (JSmol)	Interactive image
Melting point	75 °C (167 °F)
SMILES CCC(=O)O[C@](Cc1ccccc1)(c2ccccc2)[C@H](C)CN(C)C
InChI InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m1/s1 Y Key:XLMALTXPSGQGBX-GCJKJVERSA-N Y
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Angol

Főnév

propoxyphene (tsz. propoxyphenes)

1. (gyógyszertan) propoxifén

További információk

• propoxyphene - Szótár.net (en-hu)
• propoxyphene - Sztaki (en-hu)
• propoxyphene - Merriam–Webster
• propoxyphene - Cambridge
• propoxyphene - WordNet
• propoxyphene - Яндекс (en-ru)
• propoxyphene - Google (en-hu)
• propoxyphene - Wikidata
• propoxyphene - Wikipédia (angol)