ranolazine

ranolazine
Clinical data
Trade names	Ranexa, Aspruzyo Sprinkle, Corzyna
AHFS/Drugs.com	Monograph
MedlinePlus	a606015
License data	US DailyMed: Ranolazine;
Routes of; administration	By mouth
ATC code	C01EB18 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	35 to 50%
Protein binding	~62%
Metabolism	Extensive in liver (CYP3A, CYP2D6) and intestine
Elimination half-life	1.4 to 1.9 hours
Excretion	Kidney (75%) and fecal (25%)
Identifiers
	IUPAC name (RS)-N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]piperazin-1-yl]acetamide;
CAS Number	95635-55-5 ;
PubChem CID	56959;
IUPHAR/BPS	7291;
DrugBank	DB00243 ;
ChemSpider	51354 ;
UNII	A6IEZ5M406;
ChEBI	CHEBI:87681 ;
ChEMBL	ChEMBL1404 ;
Chemical and physical data
Formula	C24H33N3O4
Molar mass	427.545 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C(Nc1c(cccc1C)C)CN3CCN(CC(O)COc2ccccc2OC)CC3;
	InChI InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29) ; Key:XKLMZUWKNUAPSZ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Angol

ranolazine (tsz. ranolazines)

↑ Prescription medicines: registration of new chemical entities in Australia, 2017. Therapeutic Goods Administration (TGA) , 2022. június 21.
↑ Prescription medicines and biologicals: TGA annual summary 2017. Therapeutic Goods Administration (TGA) , 2022. június 21.
↑ Summary Basis of Decision (SBD) for Corzyna. Health Canada , 2014. október 23.
↑ Jerling, M. (2006). Clinical pharmacokinetics of ranolazine. Clinical pharmacokinetics, 45, 469-491.