sirolimus

sirolimus

Clinical data
Trade names	Rapamune, others
Other names	Rapamycin, ABI-009
License data	US DailyMed: Sirolimus
Pregnancy category	AU: C
Routes of administration	By mouth, intravenous, topical
ATC code	L04AH01 (WHO) L01EG04 (WHO), S01XA23 (WHO), QC01EB90 (WHO)
Legal status
Legal status	US: ℞-only EU: Rx-only
Pharmacokinetic data
Bioavailability	14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals
Protein binding	92%
Metabolism	Liver
Elimination half-life	57–63 hours
Excretion	Mostly fecal
Identifiers
IUPAC name (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E, 30S,32S,35R)-1,18-dihydroxy-12-{(2R)-1-[(1S,3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-2-propanyl}- 19,30-dimethoxy-15,17,21,23,29,35-hexamethyl- 11,36-dioxa-4-azatricyclo[30.3.1.0~4,9~]hexatria conta-16,24,26,28-tetraene-2,3,10,14,20-pentone
CAS Number	53123–88–9 Y
PubChem CID	5284616
DrugBank	DB00877 Y
ChemSpider	10482078 Y
UNII	W36ZG6FT64
KEGG	D00753 Y
ChEBI	CHEBI:9168 Y
ChEMBL	ChEMBL413 Y
PDB ligand	RAP (PDBe, RCSB PDB)
Chemical and physical data
Formula	C51H79NO13
Molar mass	914.187 g·mol−1
3D model (JSmol)	Interactive image
Solubility in water	0.0026
SMILES O[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]4CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)[C@@H](OC)C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N3CCCC[C@H]3C(=O)O4
InChI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 Y Key:QFJCIRLUMZQUOT-HPLJOQBZSA-N Y
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Angol

Főnév

sirolimus (tsz. sirolimuses)

1. (gyógyszertan) szirolimusz

További információk

• sirolimus - Szótár.net (en-hu)
• sirolimus - Sztaki (en-hu)
• sirolimus - Merriam–Webster
• sirolimus - Cambridge
• sirolimus - WordNet
• sirolimus - Яндекс (en-ru)
• sirolimus - Google (en-hu)
• sirolimus - Wikidata
• sirolimus - Wikipédia (angol)