sitagliptin

sitagliptin

Clinical data
Pronunciation	/sɪtəˈɡlɪptɪn/ ⓘ
Trade names	Januvia, Zituvio, others
AHFS/Drugs.com	Monograph
MedlinePlus	a606023
License data	US DailyMed: Sitagliptin
Pregnancy category	AU: B3
Routes of administration	By mouth
ATC code	A10BH01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only EU: Rx-only
Pharmacokinetic data
Bioavailability	87%
Protein binding	38%
Metabolism	Liver (CYP3A4- and CYP2C8-mediated)
Elimination half-life	8 to 14 h
Excretion	Kidney (80%)
Identifiers
IUPAC name (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
CAS Number	486460-32-6 Y
PubChem CID	4369359
IUPHAR/BPS	6286
DrugBank	DB01261 Y
ChemSpider	3571948 Y
UNII	QFP0P1DV7Z
KEGG	D08516 as salt: D06645
ChEBI	CHEBI:40237 Y
ChEMBL	ChEMBL1422 Y
Chemical and physical data
Formula	C16H15F6N5O
Molar mass	407.320418978 g·mol−1
3D model (JSmol)	Interactive image
SMILES Fc1cc(c(F)cc1F)C[C@@H](N)CC(=O)N3Cc2nnc(n2CC3)C(F)(F)F
InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1 Y Key:MFFMDFFZMYYVKS-SECBINFHSA-N Y
(verify)

Angol

Főnév

sitagliptin (tsz. sitagliptins)

1. (gyógyszertan) szitagliptin

További információk

• sitagliptin - Szótár.net (en-hu)
• sitagliptin - Sztaki (en-hu)
• sitagliptin - Merriam–Webster
• sitagliptin - Cambridge
• sitagliptin - WordNet
• sitagliptin - Яндекс (en-ru)
• sitagliptin - Google (en-hu)
• sitagliptin - Wikidata
• sitagliptin - Wikipédia (angol)