bendamustine

bendamustine
Clinical data
Trade names	Treanda, others
Other names	SDX-105
AHFS/Drugs.com	Monograph
MedlinePlus	a608034
License data	US DailyMed: Treanda;
Routes of; administration	Intravenous infusion
ATC code	L01AA09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	NA (intravenous only)
Protein binding	94–96%
Metabolism	Hydrolyzed to inactive metabolites. Two minor metabolites (M3 and M4) formed by CYP1A2
Elimination half-life	40 min (bendamustine), 3 h (M3), 30 min (M4)
Excretion	~50% urinary, ~25% fecal
Identifiers
	IUPAC name 4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;
CAS Number	16506-27-7 ;
PubChem CID	65628;
IUPHAR/BPS	7478;
DrugBank	DB06769 ;
ChemSpider	59069 ;
UNII	9266D9P3PQ;
ChEMBL	ChEMBL487253 ;
Chemical and physical data
Formula	C16H21Cl2N3O2
Molar mass	358.263 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCCN(c2ccc1c(nc(n1C)CCCC(=O)O)c2)CCCl;
	InChI InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23) ; Key:YTKUWDBFDASYHO-UHFFFAOYSA-N ;
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Angol

bendamustine (tsz. bendamustines)

↑ Prescription medicines: registration of new chemical entities in Australia, 2014. Therapeutic Goods Administration (TGA) , 2022. június 21. [2023. április 10-i dátummal az eredetiből archiválva].
↑ Bendamustine EPSL (Eugia Pharma (Australia) Pty Ltd). Therapeutic Goods Administration (TGA) , 2025. március 13.
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