cobalamin

Vitamin B₁₂

General skeletal formula of cobalamins
Stick model of cyanocobalamin (R = CN) based on the crystal structure
Clinical data
Other names	Vitamin B12, vitamin B-12, cobalamin
AHFS/Drugs.com	Monograph
MedlinePlus	a605007
License data	US DailyMed: Vitamin_b12
Routes of administration	By mouth, sublingual, intravenous (IV), intramuscular (IM), intranasal
ATC code	B03BA01 (WHO)
Legal status
Legal status	UK: OTC US: OTC
Pharmacokinetic data
Bioavailability	Readily absorbed in the distal half of the ileum.
Protein binding	Very high to specific transcobalamins plasma proteins. Binding of hydroxocobalamin is slightly higher than cyanocobalamin.
Metabolism	Liver
Elimination half-life	Approximately 6 days (400 days in the liver).
Excretion	Kidney
Identifiers
IUPAC name α-(5,6-Dimethylbenzimidazolyl)cobamidcyanide
CAS Number	68-19-9
PubChem CID	184933
DrugBank	DB00115
ChemSpider	10469504
UNII	P6YC3EG204
KEGG	D00166
ChEMBL	ChEMBL2110563
Chemical and physical data
Formula	C63H88CoN14O14P
Molar mass	1355.387955998 g·mol−1
3D model (JSmol)	Interactive image
SMILES NC(=O)C[C@@]8(C)[C@H](CCC(N)=O)C=2/N=C8/C(/C)=C1/[C@@H](CCC(N)=O)[C@](C)(CC(N)=O)[C@@](C)(N1[Co+]C#N)[C@@H]7/N=C(C(\C)=C3/N=C(/C=2)C(C)(C)[C@@H]3CCC(N)=O)[C@](C)(CCC(=O)NCC(C)OP([O-])(=O)O[C@@H]6[C@@H](CO)O[C@H](n5cnc4cc(C)c(C)cc45)[C@@H]6O)[C@H]7CC(N)=O
InChI InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72–42)32(4)54(59)73–56;1–2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31?,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1 Y Key:RMRCNWBMXRMIRW-WYVZQNDMSA-L Y

Angol

Főnév

cobalamin (tsz. cobalamins)

1. (gyógyszertan) kobalamin

További információk

• cobalamin - Szótár.net (en-hu)
• cobalamin - Sztaki (en-hu)
• cobalamin - Merriam–Webster
• cobalamin - Cambridge
• cobalamin - WordNet
• cobalamin - Яндекс (en-ru)
• cobalamin - Google (en-hu)
• cobalamin - Wikidata
• cobalamin - Wikipédia (angol)