lisdexamfetamine

lisdexamfetamine
Clinical data
Trade names	Vyvanse, Elvanse, Tyvense, others
Other names	L-Lysine-d-amphetamine; (2S)-2,6-Diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide; N-[(2S)-1-Phenyl-2-propanyl]-L-lysinamide
AHFS/Drugs.com	Monograph
MedlinePlus	a607047
License data	US DailyMed: Lisdexamfetamine;
Pregnancy; category	AU: B3;
Dependence; liability	Moderate
Addiction; liability	Moderate
Routes of; administration	By mouth
ATC code	N06BA12 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A3 (Psychoactive drugs); CA: Schedule G (CDSA I); DE: Anlage III (Special prescription form required); NZ: Class B; UK: Class B; US: Schedule II; EU: Rx-only; SE: Förteckning II;
Pharmacokinetic data
Bioavailability	Oral: 96.4%
Protein binding	20% (as dextroamphetamine)
Metabolism	Hydrolysis by enzymes in red blood cells initially, subsequent metabolism follows
Metabolites	Dextroamphetamine (and its metabolites) and L-lysine
Onset of action	Oral: <2 hours
Elimination half-life	Lisdexamfetamine: <1 hour; Dextroamphetamine: 10–12 h
Duration of action	10–14 hours
Excretion	Kidney: ~2%
Identifiers
	IUPAC name (2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide;
CAS Number	608137-32-2;
PubChem CID	11597698;
IUPHAR/BPS	7213;
DrugBank	DB01255;
ChemSpider	9772458;
UNII	H645GUL8KJ;
KEGG	D08130; as salt: D04747;
ChEMBL	ChEMBL1201222;
Chemical and physical data
Formula	C15H25N3O
Molar mass	263.385 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Dextrorotatory enantiomer
	SMILES O=C(N[C@H](Cc1ccccc1)C)[C@@H](N)CCCCN;
	InChI InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1; Key:VOBHXZCDAVEXEY-JSGCOSHPSA-N;
	(what is this?) (verify)

Angol

Főnév

lisdexamfetamine (tsz. lisdexamfetamines)

(gyógyszertan) lisdexamfetamin

További információk

lisdexamfetamine - Szótár.net (en-hu)
lisdexamfetamine - Sztaki (en-hu)
lisdexamfetamine - Merriam–Webster
lisdexamfetamine - Cambridge
lisdexamfetamine - WordNet
lisdexamfetamine - Яндекс (en-ru)
lisdexamfetamine - Google (en-hu)
lisdexamfetamine - Wikidata
lisdexamfetamine - Wikipédia (angol)