morphine

morphine

Clinical data
Pronunciation	/ˈmɔːrfiːn/
Trade names	Statex, MS Contin, Kadian, Oramorph, M-ESLON, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682133
License data	US DailyMed: Morphine
Pregnancy category	AU: C
Dependence liability	High
Addiction liability	High
Routes of administration	Inhalation, insufflation, by mouth, rectal, subcutaneous, intramuscular, intravenous, epidural, intrathecal
Drug class	Opiate
ATC code	N02AA01 (WHO)
Legal status
Legal status	AU: S8 (Controlled drug) BR: Class A1 (Narcotic drugs) CA: Schedule I DE: Anlage III (Special prescription form required) NZ: Class B UK: POM (Prescription only) / Class A US: Schedule II / Schedule III UN: Narcotic Schedules I and III EU: Rx-only
Pharmacokinetic data
Bioavailability	10% (Intranasal) 20–40% (by mouth), 36–71% (rectal), 100% (IV/IM)
Protein binding	30–40%
Metabolism	Liver: UGT2B7
Metabolites	• Morphine-3-glucuronide (90%) • Morphine-6-glucuronide (10%)
Onset of action	5 minutes (IV), 15 minutes (IM), 20 minutes (PO)
Elimination half-life	2–3 hours
Duration of action	3–7 hours
Excretion	Kidney 90%, bile duct 10%
Identifiers
IUPAC name (4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
CAS Number	57-27-2 Y 64-31-3 (neutral sulfate), 52-26-6 (hydrochloride)
PubChem CID	5288826
IUPHAR/BPS	1627
DrugBank	DB00295 Y
ChemSpider	4450907 Y
UNII	76I7G6D29C
KEGG	D08233 Y
ChEBI	CHEBI:17303 Y
ChEMBL	ChEMBL70 Y
PDB ligand	MOI (PDBe, RCSB PDB)
Chemical and physical data
Formula	C17H19NO3
Molar mass	285.343 g·mol−1
3D model (JSmol)	Interactive image
Solubility in water	HCl & sulf.: 60
SMILES CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 Y Key:BQJCRHHNABKAKU-KBQPJGBKSA-N Y
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Angol

Főnév

morphine (tsz. morphines)

1. (gyógyszertan) morfin

További információk

• morphine - Szótár.net (en-hu)
• morphine - Sztaki (en-hu)
• morphine - Merriam–Webster
• morphine - Cambridge
• morphine - WordNet
• morphine - Яндекс (en-ru)
• morphine - Google (en-hu)
• morphine - Wikidata
• morphine - Wikipédia (angol)