sertraline

sertraline

Clinical data
Pronunciation	/ˈsɜːrtrəˌliːn/ ⓘ sur-trə-LEEN
Trade names	Zoloft, Lustral, Setrona, others
AHFS/Drugs.com	Monograph
MedlinePlus	a697048
License data	US DailyMed: Sertraline
Pregnancy category	AU: C
Addiction liability	None
Routes of administration	By mouth
Drug class	Selective serotonin reuptake inhibitor (SSRI)
ATC code	N06AB06 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class C1 (Other controlled substances) CA: ℞-only NZ: Prescription only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	44%
Protein binding	98.5%
Metabolism	Liver (primarily N-demethylation mainly by CYP2B6; also metabolism by CYP2C19, others)
Metabolites	• Desmethylsertraline • Others (e.g., hydroxylated metabolites, glucuronide conjugates)
Elimination half-life	• Sertraline: 26 hours (32 hours in females, 22 hours in males; range 13–45 hours) • Desmethylsertraline: 62–104 hours
Excretion	Urine (40–45%) Feces (40–45%)
Identifiers
IUPAC name (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
CAS Number	79617-96-2 Y
PubChem CID	68617
IUPHAR/BPS	4798
DrugBank	DB01104 Y
ChemSpider	61881 Y
UNII	QUC7NX6WMB
KEGG	D02360 Y as HCl: D00825 Y
ChEBI	CHEBI:9123 Y
ChEMBL	ChEMBL809 Y
Chemical and physical data
Formula	C17H17Cl2N
Molar mass	306.23 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC=C([C@H]2C3=C([C@H](CC2)NC)C=CC=C3)C=C1Cl
InChI InChI=1S/C17H17NCl2/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 Y Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N Y
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Angol

Főnév

sertraline (tsz. sertralines)

1. (gyógyszertan) szertralin

További információk

• sertraline - Szótár.net (en-hu)
• sertraline - Sztaki (en-hu)
• sertraline - Merriam–Webster
• sertraline - Cambridge
• sertraline - WordNet
• sertraline - Яндекс (en-ru)
• sertraline - Google (en-hu)
• sertraline - Wikidata
• sertraline - Wikipédia (angol)